Sleep and immune function are increasingly interconnected areas of study within health science. Emerging research suggests that adequate sleep may support various bodily systems, including those involved in immune regulation and cellular activity (1)(3)(4). For example, during certain sleep stages, metabolic resources may shift away from physical exertion and toward repair processes, including activity in the lymphatic and endocrine systems.
Hormones such as melatonin and cortisol also follow circadian rhythms. Melatonin, which rises in response to darkness, plays a role in sleep-wake timing and has been studied for its role in regulating physiological processes, including oxidative balance (5). Cortisol, a hormone associated with stress, fluctuates throughout the day and may influence the way the body responds to environmental challenges [6].
Scientists have also explored the role of deeper sleep stages—often referred to as delta sleep—in children and adults. These stages are associated with specific brain wave patterns and may contribute to restorative functions (2).
Conditions such as chronic inflammation or neurological symptoms are under investigation for their connection to sleep quality, though much of the research is preliminary. For instance, in cases like post-treatment Lyme disease syndrome (PTLDS), patients have reported lingering symptoms even after antibiotic treatment, raising questions about how sleep and immune activity may interact (1).
As this area of research evolves, those experiencing persistent sleep or immune-related concerns are encouraged to consult qualified healthcare providers for guidance.
